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Molecular Imaging and Therapy

IMMO-TEP
Molecular Imaging and Therapy

The IMMO-TEP research group, coordinated by Carlos Platas Iglesias, David Esteban Gómez and Aurora Rodríguez Rodríguez, has a long history and extensive experience in the field of Coordination Chemistry oriented to the design of molecular systems with potential application in clinical diagnosis and therapy. His activity is focused on the synthesis of new chelating platforms highly selective against different metal ions, as well as on the study of the physicochemical properties of the complexes obtained from them by means of a wide range of experimental techniques of structural analysis and sophisticated computational methods.

Research line 1 - Development of new drugs for application in clinical diagnostic techniques.

The main objective of this line of research focuses on the design, synthesis and characterisation of contrast agents and probes based on coordination compounds for their application in different Molecular Imaging techniques commonly used in clinical diagnosis, such as Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET) or Computerised Axial Tomography (CAT).

Research line 2 - Development of radiopharmaceuticals with potential application in nuclear medicine.

This line of research is oriented towards the development of new radiopharmaceuticals based on coordination compounds for use in clinical therapy for the treatment of different pathologies. The research focuses on the development, characterisation and study of the physicochemical properties of new bifunctional chelating platforms that are easily derivatizable and capable of selectively complexing different metal radioisotopes of interest.

Research Line 3 - Computational study of molecular properties and chemical reactivity by means of DFT/CASSCF calculations.

The use of computational resources has become an indispensable tool for structural analysis of molecular compounds and a better understanding of their physicochemical properties and reactivity. In this sense, the group has a wide experience in this field, using DFT or more sophisticated methods (CASSCF/NEVPT2), as a support in the structural characterisation and analysis of the most relevant properties of molecular, supramolecular or surface systems.

Patents:

  • "Tetrazaamacrocyclic ligands and corresponding Ni(II) complexes useful as contrast agents". (Patent No. ES 2759316 A1; Extension PCT/ES2019/070746)
  • "Chelates of Lead(II) and Bismuth(III) based on trans-di-N-Picolinate tetraazamacrocycloalkanes". (Patent No. US9884881 B2)
  • "Compound for the Selective Extraction of Strontium(II) and Lead(II)". (Patent No. ES 2354666 A1)
  • "Compound for the Selective Extraction of Lanthanide Ions)". (Patent No. ES 2340129 A1)
  • "Compounds for the Removal and Recovery of Lead in Wastewater and Drinking Water". (Patent No. ES 2233187 B1)

Contracts/Conventions with companies:

  • "Computational Study on Gadolinium-based Contrast Agents" (INV 03919). Guerbet Group (France)
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IMMO-TEP maintains stable and continuous collaborations over time with other research groups of recognised national and international prestige, such as those led by the researchers:

  • Peter Caravan. Massachusetts General Hospital/Harvard Medical School. Boston, USA.
  • Mauro Botta. Università del Piemonte Orientale "Amedeo Avogadro". Alessandria, Italy.
  • Raphaël Tripier. University of Western Brittany, University of Brest. France.
  • Eva Tóth. Centre de Biophysique Moléculaire CNRS. Orléans, France.
  • Loïc J. Charbonnière. Institut Pluridisciplinaire Hubert Curien. Strasbourg, France.
  • Caterina Ramogida. Simon Fraser University. Burnaby, Canada.
  • Gyula Tircsó. University of Debrecen. Debrecen, Hungary.
  • Ali Trabolsi, New York University in Abu Dhabi, Abu Dhabi. United Arab Emirates.
  • Ona Illa Soler. Autonomous University of Barcelona. Spain.
  • Nicolas Lepareur. Centre Eugène Marquis. Rennes, France.

Also collaborates with companies in the pharmaceutical sector: Guerbet Group (France), Bracco (Italy) and Justesa (Spain).

Group members

Other information of interest

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Articles

Structural effects of the Pb2+ 6s2 lone pair activity: Eccentricity

Relevance of Oxocyclam from Palladium(II) Coordination to Radiopharmaceutical Development

  • Authors: Majer Hojorat, Julie Pineau, Cathryn H S Driver, David Esteban-Gómez, Marie Cordier, Jan Rijn Zeevart, Carlos Platas-Iglesias, Luis M P Lima, Nathalie Le Bris, Raphael Tripier
  • Details: Inorganic Chemistry
  • URL: https://pubs.acs.org/doi/10.1021/acs.inorgchem.4c01780
  • Quartile: Q1
  • CiteScore: 8
  • DOI: 10.1021/acs.inorgchem.4c01780

Water soluble Eu(III) complexes of macrocyclic triamide ligands: Structure, stability, luminescence and redox properties

  • Authors: Rabindra N.Pradhan, Sayed M. Hossain, Avinash Lakma, Dragana D. Stojkov, Tatjana Z. Verbic, Goran Angelovski, Rosa Pujales-Paradela Carlos Platas-Iglesias, Akhilesh K. Singh
  • Details: Inorganica Chimica Acta
  • URL: https://www.sciencedirect.com/science/article/pii/S0020169318313495
  • Quartile: Q2
  • CiteScore: 6
  • DOI: https://doi.org/10.1016/j.ica.2018.10.050
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